journal articles on ebola virus

Murray N Engl J Med 2020; 382:1784-1785. In other people, it causes severe illness with bruising, bleeding, and failure of many organs in the body, eventually leading to death. From this data, we expose important gaps in Ebola virus research pertinent to outbreak situations. Recently, reports of nosocomial transmission of Ebola virus to 2 nurses from the same patient in Texas (despite their use of PPE) has generated great concern and presents new challenges, particularly because there is no postexposure prophylaxis or effective antiviral therapy for Ebola, and approximately half of the cases are fatal. The Ebola outbreak that has affected West Africa for over a year has captured the attention of audiences throughout the world. We employed a transmission model that rests on the renewal process in order to clarify theoretical … Ebola virus disease (EVD) has mostly affected economically deprived countries as limited resources adversely affect a country’s infrastructure and administration. EBOV is one of the most virulen … American Research Journals An Academic Publishing House. “Ebola virus disease (EVD) is a severe, often fatal, zoonotic infection caused by a virus of the Filoviridae family (genus Ebolavirus )”. The West African Ebola epidemic has set in motion a collective endeavour to conduct accelerated clinical trials, testing unproven but potentially lifesaving interventions in the course of a major public health crisis. The tremendous outbreak of Ebola virus disease occurring in West Africa since the end of 2013 surprises by its remoteness from previous epidemics and dramatic extent. Free access until 1 October 2016. It is a severe and often fatal disease. In November 2018, the Ebola virus epidemic in North Kivu and Ituri in the Democratic Republic of the Congo (DRC) became the second-largest epidemic of Ebola virus disease and the second deadliest in history, behind that in West Africa from 2014 to 2016. Four of these viruses cause hemorrhagic fever in humans. Patients who are able to mount an immune response to the virus will begin to recover in 7 to 10 days and start a period of prolonged convalescence. Here’s a look at Ebola, a virus with a high fatality rate that was first identified in Africa in 1976.. Facts. The largest ever Ebola virus disease outbreak is ravaging West Africa. This page offers guidance for healthcare workers outside affected regions. Health. It is also the first time the disease has spread through a large urban environment. 384:1240-1247. Ebola, previously known as Ebola hemorrhagic fever, is a rare and deadly disease caused by infection with one of the Ebola virus strains. (2014) Successful delivery of RRT in Ebola virus disease. J Gen Virol 1988, 69 ( Pt 8): 1957-1967. Definition/Description. The West African Ebola epidemic has set in motion a collective endeavour to conduct accelerated clinical trials, testing unproven but potentially lifesaving interventions in the course of a major public health crisis. Ebola virus disease is considered to be zoonotic, with occasional spillovers to humans, apes, and possibly other animals. By … There are five variants of the Ebola virus, with the Zaire species being responsible for many human outbreaks, including the outbreak beginning in Guinea in December 2013 and continuing in western Africa up until the writing of this article . The 2014-16 Ebola outbreak in West Africa was an opportunity for researchers to test two experimental vaccines for safety and effectiveness. Ebola virus is transmitted via direct contact with blood, other bodily fluids or contaminated fomites.3 Spillover from animals into humans typically occurs through hunting, butchering and consumption of bushmeat (especially primates), as well as possible transmission from bats.4 Human-to-human transmission follows when people care for patients or infected family members or participate … Ebola virus-infected macaques were successfully treated with a cocktail of monoclonals manufactured in plants. Ebola virus is infamous due to its reputation in hemorrhagic fever disease outbreaks in various countries of the world including West Africa. On 17 July 2019, the Ebola virus disease outbreak in the Democratic Republic of the Congo was declared a Public Health Emergency of International Concern by the World Health Organization. Individuals infected with the Ebola virus … Ethical approval was obtained to collect plasma samples from patients in Sierra Leone infected with Ebola virus over time and samples were analysed for clotting time, fibrinogen, and D-dimer levels. Researchers believe that the virus first spreads from an infected animal to a human. View Article Google Scholar 30. Ebola virus envelope glycoprotein (GP1,2) is highly immunogenic, but antibodies frequently arise against its least conserved mucin-like domain (MLD). ISSN: 0022-1899 Date: 02/1999 It can affect humans and other primates. Ebola is caused by infection with a virus of the family Filoviridae, genus Ebolavirus. Incubation ranges from 2 to 21 days. The New England journal of medicine. Ebola first became headline news in 2014–2016 when it was transmitted throughout West Africa. We used Ebola virus-infected macaques to model humans who died of Ebola virus disease. The 2013–2016 Ebola virus (EBOV) epidemic was estimated to have caused 28,616 confirmed, probable, and suspected cases and 11,310 deaths [], but the true burden of EBOV may have been higher.The number of cases and deaths exceeded by more than two orders of magnitude those across all 29 previous outbreaks [1,2,3].No approved treatments or vaccines were available and a … We construct a mathematical model to devise the optimal Ebola virus disease eradication plan. pmid:25539447 . A novel immunohistochemical assay for the detection of Ebola virus in skin: implications for diagnosis, spread, and surveillance of Ebola hemorrhagic fever. Knowledge on haemostatic changes in humans infected with Ebola virus is limited due to safety concerns and access to patient samples. The viruses are masters of their attack, but researchers are working hard to fight them, said … 3 May 2021. Remdesivir Reduces Ebola Virus That Lingers in Semen. The continued spread is facilitated by insufficient medical facilities, poor sanitation, travel, and unsafe burial practices. Nishiura H, Wilson N, Baker MG. Ebola Cluster Traced to Vaccinated Taxi Driver Who Appeared to Recover. Ebola Virus Disease in West Africa - The First 9 Months of the Epidemic and Forward Projections. The idea here is that if an Ebola virus particle were to wind up with mutations that allowed it to be transmitted through the air, that viral lineage (i.e., the original particle's descendants) might be favored and spread because those viruses could infect new hosts more rapidly than other Ebola viruses could. 2015 Feb 5;372(6):587–8. The Ebola virus can cause severe illness and even death. Kilmarx PH, Clarke KR, Dietz PM, Hamel MJ, Husain F, McFadden JD, et al. 2). This unprecedented effort was supported by the recommendations of an ad hoc ethics panel convened in August 2014 by the WHO. Connor MJ, Kraft C, Mehta AK, Varkey JB, Lyon GM, et al. The largest ever Ebola virus disease outbreak is ravaging West Africa. The recent Ebola virus disease (EVD) outbreak in 2014–2015 has been the largest and longest lasting to date. The association of EVD outbreaks with … The international humanitarian community utilized its expertise in rapid response and scale up in emergency situations to manage a threat different from the more common … This is Pharmaceutical Journal's in-depth report on latest developments in managing the Ebola virus outbreak and the disease. 2016. Long-term sequelae of Ebola virus disease—including myalgia, arthralgia, ocular diseases, and mental confusion—have come to light in survivors of the 2014–16 Ebola outbreak in west Africa. For the Ebola virus to infect successfully, a host enzyme must digest a surface protein on the virus, suggesting a new target for treatment of this fatal infection. Fruit bats belonging to the Pteropodidae family are thought to be the natural hosts of the Ebola virus, although the virus has not been isolated yet from bats in natural conditions. The present study investigates the impact of polarity on EBOV infection using the colorectal adenocarcinoma (Caco-2) cell polarized model. Focusing on the Zaire Ebola virus (EBOV), we use a stochastic epidemiological compartmental model 29, to simulate both pathogen spill-over and subsequent human-to-human disease transmission (Fig. PubMed PMID:25244186. [24] Report of an International Commission. Original Article from The New England Journal of Medicine — A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics Ebola hemorrhagic fever is caused by a virus. Ebola virus disease is a severe, often fatal, zoonotic infection caused by a virus of the Filoviridae family (genus Ebolavirus) Human to human transmission occurs through contact with body fluids from infected patients. Here, we extract published American Journal of Roentgenology > Volume 204, Issue 1 > Radiographic Imaging for Patients With Contagious Infectious Diseases: How to Acquire Chest Radiographs of Patients Infected With the Ebola Virus

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